Familial hypercholesterolaemia and dyslipidaemia service
Hypercholesterolaemia (hyperlipidaemia, dyslipidaemia) is commonly due to factors like diet, obesity, medications or certain medical conditions.
However a small percentage is due to familial/genetic (primary hyperlipidaemia), a condition called familial hypercholesterolaemia (FH).
FH can be heterozygous FH (HeFH) or homozygous FH (HoFH). The presentation of HeFH can be with very high TC/LDL and HoFH with early CV events and signs of cholesterol deposits.
Although it is a rare disorder, it is important to detect FH as it is life threatening as it greatly increases the risk of early CV events.
The treatment of FH is usually more complex as they often fail to respond to lifestyle changes and statins used to treat the common hyperlipidaemia. Treatment is also very costly.
UiTM has been offering a specialized service for FH for many years. This includes a lipid clinic to clinically diagnose FH, a family cascade screening (screening other family members as FH usually does not occur alone), genetic testing (mutations in the LDLR, ApoB, PCSK9 genes), FH registry, medications like PCSK9i and lipid apharesis.
The team has now grown and consists of pathologists, biochemist, geneticists, paediatric and adult endocrinology, FMS, cardiology, nephrology, dietitian, social workers all working together to ensure the patient receives the correct treatment.
If you suspect FH please refer them to us. We will do our best to help them.